When Doc Ock teams up with Arnim Zola and Hydra to attack the Tri-Carrier, SHIELD finds itself caught off guard and Spider-Man must singlehandedly stop the assault.
Having lost SHIELD and his friends to Doc Ock and Hydra, Spider-Man has to assemble a new team in order to stop the villains from taking over New York.
Spider-man brings Miles Morales to our world to help stop the Goblin.
Spider-man must stop Doc Ock from eliminating Norman Osborne.
Vulture’s revelation that Doc Ock has a spy inside SHIELD Academy leads the Web Warriors on a hunt to find the mole.
Spider-Man and Scarlet Spider must overcome Kraven in order to rescue their kidnapped teammate, Agent Venom.
Spider-Man and Iron Spider discover Doc Ock has taken control of Sandman.
Doc Ock and his new assistant, Morbius, create Anti-Venom in order to destroy one of the Web Warriors.
After receiving a mysterious signal from an unknown base, Spider-Man traces it to an abandoned building in the hopes of finding Nick Fury.
Spider-Man faces the culmination of all of Doc Ock’s evil machinations when the new Sinister Six assaults the Web Warriors and SHIELD Academy at the Triskelion.
When Ock learns that the key to a device that will retrieve Hydra Island is at Aunt May's house, Spider-Man must fight to protect his family.
When a battered Nova asks for help finding Nick Fury, Spider-Man tracks him to the dangerous ruins of an ancient city.
Spider-Man and Agent Venom uncover Hydra and Morbius’ plan to create a new, improved Venom Bomb — the unstoppable Carnage Bomb.
With the Carnage Bomb already detonated, turning civilians into versions of Carnage, Spider-Man, Captain America and SHIELD Academy must band together to save New York.
Spider-Man and his fellow heroes have to defeat Morbius and his plan to use the Carnage Queen as the ultimate weapon for Hydra and Arnim Zola.
Spider-Man and Kid Arachnid travel to alternate dimensions in order to gather the shards from the broken Siege Perilous.
Spider-Man and Miles, tracking the missing pieces of the Siege Perilous, travel to a tropical Pirate dimension, where they meet Web Beard, the Spider-Pirate.
Spider-Man and Kid Arachnid arrive in the Noir Universe, where they have to prevent Mr. Negative from using the Siege Perilous to drain all the life and color out of the world.
Spider-Man, having collected all of the shards of the Siege Perilous, returns to Miles Morales’ universe and finally confronts Wolf Spider.
When trick-or-treaters start turning into monsters, Spider-Man, Dr. Strange and Ant-Man must team up to stop Baron Mordo.
Spider-Man must team with the former traitor, Scarlet Spider, to stop Doc Ock from reawakening a secret program designed to create evil duplicates of Spider-Man.
Spider-Man and Scarlet Spider have to infiltrate the sunken Hydra Island so Scarlet can destroy the lab that created him.
Spider-Man puts the Triskelion on lockdown when a mysterious villain begins to take out the heroes one at a time.
While house-sitting on Christmas Eve, Spider-Man is forced to team up with Moon Knight to defend the home from the new Mysterio.
Doctor Octopus threatens to harm Aunt May if Spidey ever puts on his mask again. Spider-Man must track down Ock before he has a chance to put his plan into effect.
Peter Parker must find a way to stop Doctor Octopus and the Superior Sinister Six from destroying all of the heroes in New York and taking over the world.