As House serves time behind bars, he attempts to solve the medical mystery behind a fellow inmate's unusual symptoms; meanwhile, a clinic doctor must decide whether to risk her job by helping House. Jaleel White and Michael Paré guest star.
An unexpected visitor offers House the chance to help the Princeton Plainsboro team with a patient, but once he's back at the hospital, he's forced to work with smart yet timid resident Dr. Chi Park; meanwhile, House attempts to reconnect with Wilson.
When a man collapses after making a generous donation, House and Park try to identify his medical disorder; meanwhile, House recruits Adams to help with the case, and Thirteen's pursuit of happiness is hampered by her guilt. Wentworth Miller guest stars.
House and the team must save the life of a businessman who becomes ill days before signing a contract that would relocate his company's labor force to China; meanwhile, Park prepares for her disciplinary hearing. Michael Nouri guest stars.
A patient under House's care confesses dark secrets to his family and community, compromising his chances of receiving life-saving medical treatment; Chase and Taub rejoin the team, and House wants Taub to do a paternity test. Jamie Bamber guest stars.
The team discovers a disturbing family secret while trying to find a bone marrow match for an ailing teen; House tries to remove his ankle monitor so he can go to a boxing match; Taub's ex-wife wants to move across the country with their daughter.
The team learns that their patient is suffering from more than teen angst when her physical symptoms worsen; meanwhile, House becomes consumed with determining the cause of a four-year-old's death. Madison Davenport guest stars.
When a prosecutor suffers cardiac arrest during an iterrogation, the team investigates his home to uncover the true source of his condition; meanwhile, Wilson sets out to prove House is hiding something. Yaya DaCosta and Blake Anderson guest star.
When an Alzheimer's patient inexplicably suffers from violent vomiting and an explosive temper, the team uncovers deep conflict in his marriage; Wilson treats a patient who claims to be in a chaste marriage. Melanie Lynskey guest stars.
House treats a homeless teenager, but when her symptoms worsen, she needs invasive surgery requiring adult consent; Taub tries to connect with his daughters; House threatens Foreman's relationship with a married woman. Yaya DaCosta guest stars.
After a violent incident involving a patient, House and the team are placed under review by Foreman's former mentor, who must weigh the team’s unconventional brand of collaboration against their ability to save lives. Jeffrey Wright guest stars.
As Chase treats a cloistered nun who is on the verge of making life-altering vows, they form a connection that causes Moira to question her faith; meanwhile, Taub and House try to remain one step ahead of each other's pranks. Julie Mond guest stars.
When a marriage counselor collapses and is put under close evaluation, the team notice changes in his behavior that conflict with his motivational message on the roles of men and women; House decides to name a team leader. Karolina Wydra guest stars.
House and the team battle to save a successful, independent blind man who is struck down by a mysterious illness; meanwhile, House’s mother unexpectedly arrives at Princeton Plainsboro. Michael B. Jordan, Diane Baker and Billy Connolly guest star.
The team treats an Army veteran who puts his life at risk when he refuses treatment unless he and his brother are given information about their dead father; meanwhile, Adams seeks help when she suspects House is sick. Sharif Atkins guest stars.
House and the team take on the case of a minor league hockey player who collapsed and coughed up blood after a fight on the ice; meanwhile, House drops a bomb on Wilson, and Chase offers to help Park change her living arrangement. Greg Finley guest stars.
House and the team take on the mysterious case of a man who sheds tears of blood; meanwhile, House acts out when his favorite prostitute decides to leave the business. Karolina Wydra and Amy Davidson guest star.
The team treats a boy who has nightmares of being choked and wakes up unable to breathe; meanwhile, Park has intimate dreams about her co-workers, and Dominika discovers a secret that could ruin her relationship with House. Karolina Wydra guest stars.
When the team treats a child with several health issues, they must collaborate with her mother, a doctor who disagrees with the girl's father about how to handle her health problems; meanwhile, Wilson and House go on vacation. Jessica Collins guest stars.
The team takes on the case of a pathologist at Princeton-Plainsboro who knows too much about the hospital staff to trust any of the physicians except House, who has mysteriously gone missing. Peter Weller and Jamie Elman guest star.
When the team takes on the case of college student who had a mysterious nose bleed during cheerleading practice, they discover that his health issues are likely both physiological and psychological. Olivia Wilde and Skylar Astin guest star.
When treating a drug addicted patient, House is forced to examine his own life, his future and his personal demons. Olivia Wilde, Jennifer Morrison, Kal Penn, Amber Tamblyn and Sela Ward guest star.