Brian's life turns extraordinary after taking a mysterious drug, NZT, that lets him access his full brain capacity; an NZT-related murder puts Brian on the FBI's radar.
Brian puts his new job at risk when he disregards orders to stay out of a renowned journalist's murder.
A retired FBI agent's murder is connected to the head of a notorious drug cartel; Brian and an old flame (Analeigh Tipton) reconnect.
Sen. Edward Morra's representative asks Brian to take the FBI's secret files on NZT; Harris makes a discovery that leaves her feeling conflicted.
Brian learns something about Rebecca's late father, but worries telling her about it would get him in trouble; Brian accidentally meddles in Rebecca's personal life.
Sen. Morra (Bradley Cooper) demands a high price for Brian's next inoculation to combat the side effects of NZT.
When Brian tries to land a day off by calling in sick, the CIA abducts him for a black-ops mission; without support from the FBI, Brian's situation spirals out of control.
Brian and Rebecca work to clear Naz's name when she is accused of funding terrorism; Naz's daughter reveals a family secret.
In exchange for his personal headquarters at the agency, Brian offers to catch the FBI's 10 most wanted criminals in two weeks; a rift grows between Brian and his father.
Boyle's friend is accused of murder after losing control of his prosthetic arm; Boyle asks Brian to prove the limb was hacked.
Agent Casey Rooks (Desmond Harrington) and his team try to skim NZT pills for themselves, triggering an internal investigation.
When a former member of Sen. Morra's inner circle makes an attempt on his life, Brian must sabotage the FBI's investigation of the attack.
For his first field assignment, Brian goes to Quantico to help the unit that catches serial killers; Rebecca gets closer to discovering Sen. Morra's connection to NZT.
Brian and Rebecca interview a robotic version of a murder victim that was created before her demise; Brian screens potential bodyguards who would work with Mike and Ike.
Brian develops a connection with a tenacious, rule-breaking FBI agent (Christina Vidal); Sands tries to end Rebecca's investigation into Sen. Morra.
When Sands asks Brian for help eliminating a threat, Brian learns about Sands' past; when the FBI cannot reach Brian, his sister, Rachel, tries to cover up his side mission with Sands.
When Brian and Rebecca investigate a citywide blackout, they are exposed to an unknown substance and placed under quarantine; Rebecca catches Brian using NZT from his private stash.
With his closest relationships shattered, Brian goes rogue from the FBI to try to free himself from Sen. Eddie Morra's control; Brian searches for an adversary in Russia; Rebecca is one step closer to discovering Brian's connection to NZT.
Following his rogue trip to Russia, Brian is placed under FBI surveillance; Sen. Morra makes contact with Brian; Rebecca finds out about Brian's encounter with Morra's henchman.
After learning the truth about her father's death, Rebecca takes NZT to seek justice for his murder; Sands makes a move against Brian.
The FBI and the Department of Justice race to find the lab producing NZT as the drug floods the streets of New York City, threatening to become a national epidemic.
Brian and the FBI go after an NZT-enabled Sands and his associates to stop them from orchestrating an international incident; Brian has terrible side effects when his NZT immunity begins to wear off.