Diagnosed with schizophrenia, Owen is the black sheep of the wealthy Milgrim clan; after losing his job, he enrolls in an experimental drug trial.
When her pilfered stash of pills runs out, troubled Annie tries to quit -- but ends up blackmailing her way into the Neberdine study.
Muramoto notices irregularities in Annie and Owen's data; he questions Owen, who recalls the worst night of his life -- his brother's engagement party.
After taking the B pill, Annie and Owen find themselves on 1980s Long Island entangled in a strange caper involving a lemur.
Annie and Owen are Arlie and Ollie, grifters attending a séance at the mysterious Neberdine mansion in the 1940s.
Azumi tells James the whole truth about the study's snags and urges him to call his estranged mother, an esteemed therapist.
Owen and Annie take the C pill; no longer connected, he belongs to a Mafia family and she's a medieval guide hired by an ailing elf princess.
Annia and Ellia continue their quest, and Owen's Mafioso father pressures him to protect the family; Greta counsels a bereaved Gertie.
Owen and Annie meet again as a disgraced Icelandic spy and a CIA operative who helps him; Greta implores James to shut down the trial.
After the subjects are discharged, James and Azumi face Neberdine's CEO; Owen and Annie part ways -- until a startling headline sparks a reunion.