As House serves time behind bars, he attempts to solve the mystery behind a fellow inmate's unusual symptoms; meanwhile, a clinic doctor must decide whether to risk her job by helping House.
An unexpected visitor offers House the chance to help the Princeton Plainsboro team with a patient, but once he's back at the hospital, he's forced to work with a smart yet timid resident.
When a man collapses after making a generous donation, House and Park try to identify his medical disorder; meanwhile, House recruits Adams to help with the case.
House and the team must save the life of a businessman who becomes ill days before signing a contract that would relocate his company's labor force to China.
A patient under House's care confesses dark secrets to his family and community, compromising his chances of receiving life-saving medical treatment; meanwhile, Chase and Taub rejoin the team.
The team discovers a disturbing family secret while trying to find a bone marrow match for an ailing teen; House tries to remove his ankle monitor so he can go to a boxing match.
The team learns that their patient is suffering from more than teen angst when her physical symptoms worsen; House becomes consumed with determining the cause of a four-year-old's death.
When a prosecutor suffers cardiac arrest, the team investigates his home to uncover the true source of his condition; meanwhile, Wilson sets out to prove House is hiding something.
When an Alzheimer's patient suffers from violent vomiting and an explosive temper, the team uncovers deep conflict in his marriage; Wilson treats a patient who claims to be in a chaste marriage.
House treats a homeless teenager, but when her symptoms worsen, she needs invasive surgery requiring adult consent; Taub tries to connect with his daughters.
After a violent incident involving a patient, House and the team are placed under review by Foreman's former mentor. Jeffrey Wright guest stars.
As Chase treats a cloistered nun who is on the verge of making life-altering vows, they form a connection that causes Moira to question her faith; Julie Mond guest stars.
When a marriage counselor collapses and is put under close evaluation, the team notice changes in his behavior that conflict with his motivational message on the roles of men and women.
House and the team battle to save a successful, independent blind man who is struck down by a mysterious illness; meanwhile, House’s mother unexpectedly arrives at Princeton Plainsboro.
The team treats an Army veteran who refuses treatment unless he and his brother are given information about their dead father; Adams seeks help when she suspects House is sick.
House and the team take on the case of a minor league hockey player who collapsed and coughed up blood after a fight on the ice; meanwhile, House drops a bomb on Wilson.
House and the team take on the mysterious case of a man who sheds tears of blood; meanwhile, House acts out when his favorite prostitute decides to leave the business.
The team treats a boy who has nightmares of being choked and wakes up unable to breathe; meanwhile, Dominika discovers a secret that could ruin her relationship with House.
When the team treats a child with several health issues, they must collaborate with her mother, a doctor who disagrees with the girl's father about how to handle her health problems.
The team takes on the case of a pathologist at Princeton-Plainsboro who knows too much about the hospital staff to trust any of the physicians except House, who has mysteriously gone missing.
When the team takes on the case of college student who had a mysterious nose bleed during cheerleading practice, they discover his health issues are likely both physiological and psychological.
When treating a drug addicted patient, House is forced to examine his own life, future and personal demons. Olivia Wilde, Jennifer Morrison, Kal Penn, Amber Tamblyn and Sela Ward guest star.