As Brooke and Julian begin to adjust to life with their new children, Haley and Nathan find themselves dealing with similar issues. Although they don't know it yet, faces from the past threaten to interrupt plans for all their futures. Meanwhile, a mysterious problem arises for Clay and Quinn.
Brooke discusses a new business venture with her father, as Julian stresses about his own investment. Quinn convinces Clay to get help, and Millie struggles to be honest with Mouth. Meanwhile, Chris Keller makes Alex an offer she may not be able to refuse and Nathan volunteers to scout in Europe,...
As Julian deals with his guilt, Brooke helps Haley confront a new rival café, and its difficult owner. Meanwhile, Chase's new girl has a complicated secret, and Quinn takes extreme measures that help Clay realize he's worse off than he thought.
As Quinn distracts Jamie, Haley searches for Nathan. Clay finally gets answers about his condition. Meanwhile, Julian attempts to get back to a normal life, while Brooke tries to give Tara a chance.
Dan enlists Julian to help in his search for Nathan. Mouth fills Clay in about Nathan, as Haley explains Nathan's disappearance to Jamie. Brooke gets an idea of how to bring patrons to an empty Karen's Café, and Chris Keller confronts Chase about Tara.
Haley seeks help from Lucas as Nathan makes an escape attempt. Brooke comes face-to-face with Xavier. Juliain uncovers evidence that assists Dan in his search for Nathan. Clay makes a connection with another patient.
Haley receives news of a possible tragedy. Dan's search for Nathan leads him back to his dark past. Clay has a breakthrough in his treatment. Brooke and Julian deal with Xavier. Chase's concern for Chuck pushes him to his limits.
Brooke and Julian take new measures to protect their family. Skills helps Mouth get to a turning point, and Chase faces consequences for defending Chuck. Clay reaches a new understanding with Logan.
Dan, Julian and Chris Keller attempt to rescue Nathan. Brooke's conflict with Xavier escalates. Quinn and Clay revisit the past.
The search for Nathan becomes increasingly dangerous, and Dan's life hangs in the balance. Brooke is surprised when her father returns. And Clay and Quinn reconnect with Logan.
In the final chapter of One Tree Hill, the tenth anniversary of Tric brings old faces and new possibilities for the Tree Hill family.