Out of the ashes of humanity's nuclear war, Night Eternal has begun. Haunted by the atrocities committed by his son, Eph abandons NYC for Philadelphia. His solitude is cut short when he encounters new fighters who rekindle his drive to fight back. Tasked by Setrakian, Fet and Quinlan search for a...
The fates of Gus and Dutch are revealed, while Eph continues to help Alex and her brother.
While Vasiliy and Quinlan try to obtain a nuclear warhead, Eph leads a strike against the strigoi in Philadelphia... alerting the Master and Eichhorst to his presence. Meanwhile, Zach makes a new friend.
Dutch is forced to make a deal with Desai while she plots to escape a strigoi breeding facility. Eph and Alex seek to uncover the dark secrets behind the Partnership's new plan but face the repercussion of their last attack.
While Vasiliy and Quinlan acquire the nuclear pit from the strigoi convoy, Eph and Alex head for New Horizons to discover it's secret. Meanwhile, Dutch leads a rebellion and finds Abraham, while in the past, Quinlan finds a moment of happiness.
Fet and Quinlan have to figure out how to get the nuclear bomb back to New York, while a desperate Eichhorst draws near. Love-struck Zack tries to learn more about his new crush, but makes a devastating discovery.
His health failing, Setrakian ignores Eph's warnings, pushing himself to the limit in his quest for victory and revenge. Fet and Quinlan race back to Manhattan, while the Master seals off the city and prepares to eliminate them all.
Before he has Quinlan kill him, Abraham tells the others how to defeat the Master. They begin by assaulting the Partnership facility and capturing Desai. Meanwhile, the Master sends Zack on a special mission.
An unexpected guest brings old conflicts to the surface, dividing our heroes, threatening the group's trust. With questionable new intel in hand, they launch a make-or-break final assault on the Master.
Quinlan devises a desperate plan, but the costs are enormous. Eph wrestles with his conscience, Fet undertakes a suicide mission, and Dutch and Gus dig in for battle as humankind makes its final stand against the Master and his Strain.